Introduction: Rubella infection in pregnancy results in abortion, fetal death or Congenital Rubella Syndrome. It has been since many years that the titer of rubella antibody in children and women in the reproductive age group is measured in order to have a proper vaccination program for the control of rubella and its complications. The aim was to study the immunity of women in the reproductive age group in Birjand so as to apply the obtained data for the health program. Material and methods: This research was a descriptive study done on 271 women referring to the treatment and health center for routine pre-marriage tests. The antibody titer was detected by the ELISA method using an American23 kit (Trinity Biotech). The results were statistically evaluated with SPSS program. Results: This study showed that of the 271 case, 95.2% were immune and 4.8% were sensitive to rubella. There was no significant relationship with age, living place, parent’s education, level of education and number of children in the family. Conclusion: Considering the lack of immunity against rubella in 4.8% of women at reproductive age, vaccination for girls at the age of marriage seems to be necessary.

Keywords: Rubella, Congenital Rubella Syndrome, Rubella Antibody

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