Introduction: Considering high prevalence of addiction, the age range of drug abuse and availability of new synthetic drugs, evaluation of knowledge of adolescents about drugs would be a priority in research. Methods: In this descriptive cross-sectional study, 517 rural high school students were asked to complete a questionnaire and through SPSS soft ware version 13, collected data was analyzed by chi-square and analysis of variance tests. Results: 7.1% of rural families with at least one boy in high school had an addict family member. 70.2% of high school students had had a contact with an addict and 42.5% knew an adolescent addict. Also, 17.5% had been offered drugs and 37.9% of high school students claimed that there was at least one addict in their family or relations. Conclusion: Considering the frequency of addiction in families and rate of invitation to drug abuse in students, there is a high risk of increment of addiction in high schools and therefore real and urgent need to do an intervention.

Keywords: Knowledge, Rural Population, Street Drugs

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