Effect of a 10-week combined exercise training on new fatty liver markers in women with type 2 diabetes

Banitalebi, Ebrahim; Mardaniyan ghahfarrokhi, Majid; Faramarzi, Mohammad; Nasiri, Samira

Volume 26, Issue 3 (Jun 2018) JSSU 2018, 26(3): 200-214 | Back to browse issues page

Mendeley

Zotero

RefWorks

Banitalebi E, Mardaniyan ghahfarrokhi M, Faramarzi M, Nasiri S. Effect of a 10-week combined exercise training on new fatty liver markers in women with type 2 diabetes . JSSU 2018; 26 (3) :200-214
URL: http://jssu.ssu.ac.ir/article-1-4657-en.html

Effect of a 10-week combined exercise training on new fatty liver markers in women with type 2 diabetes

Ebrahim Banitalebi ^*

, Majid Mardaniyan ghahfarrokhi

, Mohammad Faramarzi

, Samira Nasiri

Abstract: (5310 Views)

Introduction: Fatty liver is a condition in people with type 2 diabetes mellitus (T2DM). The purpose of this study is to examine the effects of combined training on novel hepatic steatosis indices (fatty liver index (FLI), accumulation product (LAP), hepatic steatosis index (HSI), and Framingham steatosis index (FSI)) in women with type 2 diabetes.

Methods: 35 female with type 2 diabetes were assigned to combined training (n = 17) and control (n = 18). Intervention consisted of combined (aerobic-strength training) for 10 weeks. Data were analyzed using dependent t test to compare pretest and posttest in each group. The Analysis of covariance (ANCOVA) was used to compare the amount of changes in experimental and control training groups after 10 weeks.

Results: The results of the analysis of covariance showed that 10 weeks of combined training caused a non-significant decrease in HSI (P = 0.596), FSI (P = 0.312), FLI (P = 0.327) and a significant decrease in LAP (P = 0.334) compared to the control group.
Conclusion: The results show that 10-week combined training results in a significant decrease in LAP index and a non-significant reduction in FSI, HSI, and FLI indices of women with type 2 diabetes. Therefore, combined training recommended for improve the fatty liver in women with type 2 diabetes.

Keywords: Aerobic Training, Resistance Training, Fatty liver, Type 2 Diabetes Mellitus

Full-Text [PDF 1058 kb] (3154 Downloads)

Received: 2018/08/8 | Accepted: 2018/08/14 | Published: 2018/08/14

References

1. Booth F, Laye MJ. The future: genes, physical activity and health. Acta Physiol 2010; 199(4): 549-56.

2. Veluswamy SK, Babu AS, Sundar LM. Complementary role of herbal medicine and exercise in cardiovascular disease prevention and management: A review of evidence. Curr Pharm Des 2017; 23(8): 1253-64.

3. Saponaro C, Gaggini M, Gastaldelli A. Nonalcoholic fatty liver disease and type 2 diabetes: common pathophysiologic mechanisms. Curr Diab Rep 2015; 15(6): 607.

4. Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 2011; 364(13): 1218-29.

5. Anton SD, Manini TM, Milsom VA, Dubyak P, Cesari M, Cheng J, et al. Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial. Clin interv Aging 2011; 6: 141-9.

6. 6- Lennon E, Mathis E, Ratermann A. Comparison of strength changes following resistance training using free weights and machine weights. Missouri J Health, Physical Edu Rec Dance 2010; 9.

7. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 2006; 6(1): 9.

8. Shahmohammadi HA, Hosseini SA, Hajiani E, Malehi AS, Alipour M. Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Hepatitis Monthly 2017;17(4).

9. Kwak C-J, Kim YL, Lee SM. Effects of elastic-band resistance exercise on balance, mobility and gait function, flexibility and fall efficacy in elderly people. J Phys Ther Sci 2016; 28(11): 3189-96.

10. Fedchuk L, Nascimbeni F, Pais R, Charlotte F, Housset C, Ratziu V. Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2014; 40(10): 1209-22.

11. Golzari Z, Shabkhiz F, Soudi S, Kordi MR, Hashemi SM. Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis. Int Immunopharm 2010;10(11):1415-9.

12. Colberg SR, Albright AL, Blissmer BJ, Braun B, Chasan-Taber L, Fernhall B, et al. Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sport Exe 2010; 42(12): 2282-303.

13. Balducci S, Zanuso S, Cardelli P, Salvi L, Bazuro A, Pugliese L, et al. Effect of high-versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the Italian Diabetes and Exercise Study (IDES). PloS one 2012; 7(11): e49297.

14. 14- Paluch AE, Church TS, Blair SN. Effect of an Intensive Exercise Intervention Strategy on Modifiable Cardiovascular Risk Factors in Subjects with Type 2 Diabetes Mellitus. Current Cardiovascular Risk Report 2011; 5(6): 481.

15. 15- Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology 2013; 58(4): 1287-95.

16. Stewart KJ, Bonekamp S, Barone BB, Bacher AC, Potrekus K, Moxley J, et al. Exercise Training Reduces Hepatic Fat in Type 2 Diabetes: A Randomized, Controlled Trial. J Cardiopulmonary Rehabilitation and Prevention 2008; 28(4): 269.

17. Balducci S, Cardelli P, Pugliese L, D’Errico V, Haxhi J, Alessi E, et al. Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES). Diabet Res clinical practice 2015; 109(2): 355-63.

18. Turner L, Shamseer L, Altman DG, Weeks L, Peters J, Kober T, et al. Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev 2012.

19. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes. Diabetes care 2010; 33(12): e147-e67.

20. Larose J, Sigal R, Khandwala F, Kenny G. Comparison of strength development with resistance training and combined exercise training in type 2 diabetes. Scand J Med Sci Sport 2012; 22(4): e45-54.

21. Higgins TP, Baker MD, Evans S-A, Adams RA, Cobbold C. Heterogeneous responses of personalised high intensity interval training on type 2 diabetes mellitus and cardiovascular disease risk in young healthy adults. Clin Hemorheol Microcirc 2015; 59(4): 365-77.

22. Han TS, Feskens EJ, Lean ME, Seidell JC. Associations of body composition with type 2 diabetes mellitus. Diabet Med 1998; 15(2): 129-35.

23. Froelicher VF, Thompson A, Noguera I, Davis G, Stewart AJ, Triebwasser JH. Prediction of maximal oxygen consumption: comparison of the Bruce and Balke treadmill protocols. Chest 1975; 68(3): 331-6.

24. Astorino TA, Rohmann RL, Firth K. Effect of caffeine ingestion on one-repetition maximum muscular strength. Eur J Appl physiol 2008; 102(2): 127-32.

25. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European J endocrinology 2007; 157(5): 625-31.

26. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 6(1): 33.

27. Motamed N, Sohrabi M, Ajdarkosh H, Hemmasi G, Maadi M, Sayeedian FS, et al. Fatty liver index vs waist circumference for predicting non-alcoholic fatty liver disease. World J Gastroenterol 2016; 22(10): 3023-30.

28. Blaslov K, Zibar K, Bulum T, Duvnjak L. Effect of exenatide therapy on hepatic fat quantity and hepatic biomarkers in type 2 diabetic patients. Clin Res Hepatol Gastroenterol 2014; 38(3): e61-3.

29. Chiang JK, Koo M. Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in Taiwanese people aged 50 and over. BMC Cardiovasc Disord 2012; 12(1): 78.

30. Xia C, Li R, Zhang S, Gong L, Ren W, Wang Z, et al. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals. Eur J Clin Nutr 2012; 66(9): 1035-8.

31. Oh JY, Sung YA, Lee HJ. The lipid accumulation product as a useful index for identifying abnormal glucose regulation in young Korean women. Diabet Med 2013; 30(4): 436-42.

32. Lee J-H, Kim D, Kim HJ, Lee C-H, Yang JI, Kim W, et al. Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis 2010; 42(7): 503-8.

33. Kahl S, Straßburger K, Nowotny B, Livingstone R, Klüppelholz B, Keßel K, et al. Comparison of liver fat indices for the diagnosis of hepatic steatosis and insulin resistance. PloS one 2014; 9(4): e94059.

34. Long MT, Pedley A, Colantonio LD, Massaro JM, Hoffmann U, Muntner P, et al. Development and Validation of the Framingham Steatosis Index to Identify Persons With Hepatic Steatosis. Clinical Gastroenterology Hepatology 2016; 14(8): 1172-80.

35. Obika M, Noguchi H. Diagnosis and evaluation of nonalcoholic fatty liver disease. Experimental Diabet Res 2012; 2012.

36. Machado MV, Cortez-Pinto H. Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J Hepatology 2013; 58(5): 1007-19.

37. Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, et al. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clinical Sci 2015; 129(12): 1097-105.

38. Church TS, Kuk JL, Ross R, Priest EL, Biltoff E, Blair SN. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 2006; 130(7): 2023-30.

39. Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, et al. High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease. Sci Rep 2017; 7.

40. Barsalani R, Riesco E, Lavoie J, Dionne I. Effect of exercise training and isoflavones on hepatic steatosis in overweight postmenopausal women. Climacteric 2012; 16(1): 88-95.

41. Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki–Järvinen H. Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroent 2008; 135(1): 122-30.

42. Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroent 2007; 133(2): 496-506.

43. Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, et al. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol-Gastrointest Liver Physiol 2008; 294(3): G619-G26.

44. Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, et al. Habitual physical activity is associated with intrahepatic fat content in humans. Diabete Care 2007; 30(3): 683-8.

45. Sambataro M, Perseghin G, Lattuada G, Beltramello G, Luzi L, Pacini G. Lipid accumulation in overweight type 2 diabetic subjects: relationships with insulin sensitivity and adipokines. Acta Diabetologica 2013; 50(3): 301-7.

46. Briganti S, Ermetici F, Malavazos AE, Dozio E, Giubbilini P, Rigolini R, et al. Effect of an isocaloric diet containing fiber-enriched flour on anthropometric and biochemical parameters in healthy non-obese non-diabetic subjects. J Clin Biochem Nutr 2015; 57(3): 217-22.

47. 47- Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, et al. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia 2016; 59(1): 56-66.

48. 48- Toohey K, Semple S, Pumpa K, Cooke J, Arnold L, Craft P, et al. High-intensity interval training versus continuous moderate intensity training: Effects on health outcomes and cardiometabolic disease risk factors in cancer survivors: A pilot study. J Sci Med Sport 2015; 19: 94.

49. 49- Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009; 50(4): 1105-12.

50. 50- Sigal RJ, Fisher S, Halter JB, Vranic M, Marliss EB. The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique. Diabet 1996; 45(2): 148-56.

51. 51- Trovato FM, Catalano D, Martines GF, Pace P, Trovato GM. Mediterranean diet and non-alcoholic fatty liver disease: the need of extended and comprehensive interventions. Clin Nutr 2015; 34(1): 86-8.

52. 52- Whyte LJ, Gill JM, Cathcart AJ. Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men. Metabolism 2010; 59(10): 1421-8.

53. 53- Hamed NS, Raoof NALA. Effect of high intensity interval training on diabetic obese women with polyneuropathy: a randomized controlled clinical trial. Physical Therapy Rehabilitation 2014;1(1): 4.

54. 54- Francois ME, Little JP. Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes. Diabet Spectr 2015; 28(1): 39-44.