A review on tissue engineering scaffolds and their function in regenerative medicine

Afzali, Maede; Mirhosseini, Mahboubeh; Molla Hoseini, Hosein; Nikukar, Habib

Volume 26, Issue 2 (May 2018) JSSU 2018, 26(2): 126-140 | Back to browse issues page

Mendeley

Zotero

RefWorks

Afzali M, Mirhosseini M, Molla Hoseini H, Nikukar H. A review on tissue engineering scaffolds and their function in regenerative medicine . JSSU 2018; 26 (2) :126-140
URL: http://jssu.ssu.ac.ir/article-1-4336-en.html

A review on tissue engineering scaffolds and their function in regenerative medicine

Maede Afzali

, Mahboubeh Mirhosseini

, Hosein Molla Hoseini

, Habib Nikukar ^*

Abstract: (6168 Views)

One of the challenges that medical sciences has long been facing is to find the best therapeutic method for the damaged tissues. The main purpose of tissue engineering and regenerative medicine is the development of biological implant or engineered tissues to repair, regenerate or replace the damaged tissue and maintain the organ function. At the moment, a lot of research has been done in the field of nanotechnology on the application of nanomaterials in medicine, because the surface of these nanomaterials increases with decreasing their size with change or increases in effect concommitantly. In recent decades, the production of medical textiles (Including nano fibers) has been provided good services to the regenerative medicine. In the field of biomedical applications, it is often necessary to combine biological and medical sciences with materials science and engineering. One of the most important application of tissue engineering is the usage of nanofiber matrix as scaffolds for the cell growth and proliferation. In this paper, various types of engineered scaffolds and their functions have been presented and evaluated.

Keywords: Scaffold, Nanofiber, Tissue Engineering, Electrospinning

Full-Text [PDF 1054 kb] (11605 Downloads)

Type of Study: Review article | Subject: Biology
Received: 2017/09/24 | Accepted: 2018/02/10 | Published: 2018/07/18

References

1. Rathjen D, Read L. Nanotechnology. Enabling technologies for Australian innovative industries. PMSEIC. 2005:1-39.

2. Siegel RW, Fougere GE. Mechanical properties of nanophase metals. Nanostructured Materials. 1995;6(1):205-16.

3. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010;10(9):3223-30.

4. Zhang L, Webster TJ. Nanotechnology and nanomaterials: promises for improved tissue regeneration. Nano today 2009; 4(1): 66-80.

5. Armentano I, Dottori M, Fortunati E, Mattioli S, Kenny J. Biodegradable polymer matrix nanocomposites for tissue engineering: a review. Polymer degradation stability 2010; 95(11): 2126-46.

6. Dhandayuthapani B, Yoshida Y, Maekawa T, Kumar DS. Polymeric scaffolds in tissue engineering application: a review. International J Polymer Sci 2011; 2011.

7. Langer R, Tirrell DA. Designing materials for biology and medicine. Nature 2004; 428(6982): 487.

8. Fang Z, Starly B, Sun W. Computer-aided characterization for effective mechanical properties of porous tissue scaffolds. Computer-Aided Design 2005; 37(1): 65-72.

9. Niknejad H, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian AM. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater 2008; 15: 88-99. [Persian]

10. Yang S, Leong K-F, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001; 7(6): 679-89.

11. Polak JM, Bishop AE. Stem cells and tissue engineering: past, present, and future. Ann Y Acad Sci 2006; 1068(1): 352-66.

12. Rezwan K, Chen Q, Blaker J, Boccaccini AR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterial 2006; 27(18): 3413-31.

13. O'brien FJ. Biomaterials & scaffolds for tissue engineering. Materials Today 2011; 14(3): 88-95.

14. Khang G, Lee SJ, Kim MS, Lee H. Biomaterials: Tissue Engineering and Scaffolds. Encyclopedia of Medical Devices and Instrumentation: J. G. Webster 2006.

15. Lyons F, Partap S, O'Brien FJ. Part 1: scaffolds and surfaces. Technology and health care : official journal of the European Society for Engineering and Medicine. 2008;16(4):305-17.

16. Babensee JE, Anderson JM, McIntire LV, Mikos AG. Host response to tissue engineered devices. Advanced drug delivery reviews 1998; 33(1):111-39.

17. Karande T, Agrawal C. Function and Requirement of Synthetic Scaffolds in Tissue Engineering: Boca Raton, FL: CRC Press; 2008.

18. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21(24):2529-43.

19. Ko HC, Milthorpe BK, McFarland CD. Engineering thick tissues-the vascularisation problem. Eur Cell Mater 2007; 14(1): 18-9.

20. Phelps EA, Garcia AJ. Update on therapeutic vascularization strategies. Regen Med 2009; 4(1): 65-80.

21. Garg T, Singh O, Arora S, Murthy RS. Scaffold: a novel carrier for cell and drug delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems 2012; 29(1).

22. Pariente JL, Kim BS, Atala A. In vitro biocompatibility assessment of naturally derived and synthetic biomaterials using normal human urothelial cells. J Biomed Material Res 2001; 55(1): 33-9.

23. Pariente J-L, Kim B-S, Atala A. In vitro biocompatibility evaluation of naturally derived and synthetic biomaterials using normal human bladder smooth muscle cells. J urology 2002; 167(4): 1867-71.

24. Grikscheit TC, Vacanti JP. The history and current status of tissue engineering: the future of pediatric surgery. J pediatric surgery 2002; 37(3): 277-88.

25. Chen F, Li X, Mo X, He C, Wang H, Ikada Y. Electrospun chitosan-P (LLA-CL) nanofibers for biomimetic extracellular matrix. J Biomaterials Sci, Polymer Edition 2008; 19(5): 677-91.

26. Jeong SI, Lee A-Y, Lee YM, Shin H. Electrospun gelatin/poly (L-lactide-co-ε-caprolactone) nanofibers for mechanically functional tissue-engineering scaffolds. J Biomaterials Sci Polymer Edition 2008; 19(3): 339-57.

27. Kleinman H, Rohrbach D, Terranova V, Varner H, Hewitt A, Grotendorst G, et al. Collagenous matrices as determinants of cell function. Immunochemistry extracellular matrix 1982; 2: 151-74.

28. Bell E, Rosenberg M, Kemp P, Gay R, Green G, Muthukumaran N, et al. Recipes for reconstituting skin. J Biomech Engineer 1991; 113(2): 113-9.

29. Pachence JM. Collagen based devices for soft tissue repair. J Biomed Material Res 1996; 33(1): 35-40.

30. Lee CH, Singla A, Lee Y. Biomedical applications of collagen. Inter J pharmaceutics 2001; 221(1): 1-22.

31. Silver FH, Pins G. Cell growth on collagen: a review of tissue engineering using scaffolds containing extracellular matrix. J long-term Effects Medical Implant 1991; 2(1): 67-80.

32. Sams AE, Nixon AJ. Chondrocyte-laden collagen scaffolds for resurfacing extensive articular cartilage defects. Osteoarthritis and Cartilage 1995; 3(1): 47-59.

33. Currie LJ, Sharpe JR, Martin R. The use of fibrin glue in skin grafts and tissue-engineered skin replacements. Plast Reconstr Surg. 2001;108:1713-26.

34. Grigolo B, Roseti L, Fiorini M, Fini M, Giavaresi G, Aldini NN, et al. Transplantation of chondrocytes seeded on a hyaluronan derivative (Hyaff®-11) into cartilage defects in rabbits. Biomaterials 2001; 22(17): 2417-24.

35. Um IC, Fang D, Hsiao BS, Okamoto A, Chu B. Electro-spinning and electro-blowing of hyaluronic acid. Biomacromolecules 2004; 5(4): 1428-36.

36. Smidsrød O, Skja G. Alginate as immobilization matrix for cells. Trends Biotech1990 ; 8: 71-8.

37. Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Sci 1980; 210(4472): 908-10.

38. Tonnesen HH, Karlsen J. Alginate in drug delivery systems. Drug development and industrial pharmacy. 2002;28(6):621-30.

39. Rajkhowa R, Tsuzuki T, Wang X-G. Recent innovations in silk biomaterials. J fiber bioengineering inform 2010; 2(4): 583-93.

40. Zhu Z, Ohgo K, Asakura T. Preparation and characterization of regenerated Bombyx mori silk fibroin fiber with high strength. Express Polymer Letters 2008; 2(12): 885-9.

41. Mourya V, Inamdar NN. Chitosan-modifications and applications: opportunities galore. Reactive and Functional Polymers 2008; 68(6): 1013-51.

42. Ma PX, Langer R. Degradation, Structure and Properties of Fibrous Nonwoven Poly(Glycolic Acid) Scaffolds for Tissue Engineering. MRS Proceedings. 2011;394:99.

43. Reed A, Gilding D. Biodegradable polymers for use in surgery—poly (glycolic)/poly (Iactic acid) homo and copolymers: 2. In vitro degradation. Polymer 1981; 22(4): 494-8.

44. Eling B, Gogolewski S, Pennings AJ. Biodegradable materials of poly(l-lactic acid): 1. Melt-spun and solution-spun fibres. Polymer. 1982;23(11):1587-93.

45. 45- Zhang R, Ma P. Degradation behavior of porous poly ( alpha-hydroxy acids)/hydroxyapatite composite scaffolds. Polymer Preprints(USA) 2000; 41(2): 446-455.

46. 46- Hench LL. Bioceramics: from concept to clinic. J American Ceramic Society 1991; 74(7): 1487-510.

47. 47- Cascone M, Barbani N, Giusti CC, Ciardelli G, Lazzeri L. Bioartificial polymeric materials based on polysaccharides. J Biomaterials Sci Polymer Edition 2001; 12(3): 267-81.

48. 48- Ciardelli G, Chiono V, Vozzi G, Pracella M, Ahluwalia A, Barbani N, et al. Blends of poly-(ε-caprolactone)and polysaccharides in tissue engineering applications. Biomacromolecules 2005;6 (4): 1961-76.

49. 49- Roether J, Boccaccini AR, Hench L, Maquet V, Gautier S, Jérôme R. Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications. Biomaterial 2002; 23(18): 3871-8.

50. 50- Zhou H, Lee J. Nanoscale hydroxyapatite particles for bone tissue engineering. Acta biomaterialia 2011; 7(7): 2769-81.

51. 51- Mirtchi AA, Lemaitre J, Terao N. Calcium phosphate cements: Study of the β-tricalcium phosphate—monocalcium phosphate system. Biomaterials 1989; 10(7): 475-80.

52. 52- Hench LL. The story of Bioglass. J Material Science: Materials in Medicine 2006; 17(11): 967-78.

53. 53- Liu X, Morra M, Carpi A, Li B. Bioactive calcium silicate ceramics and coatings. Biomedicine & Pharmacotherapy 2008; 62(8): 526-9.

54. 54- Simchi A. Introduction to nanoparticles, properties, production methods and applications. Scientific Publishing Institute. Sharif Uni Techno Tehran 2012; (2): 29-36. [Persian]

55. 55- Burg KJ, Porter S, Kellam JF. Biomaterial developments for bone tissue engineering. Biomaterials 2000; 21(23): 2347-59.

56. 56- Ramakrishna S, Mayer J, Wintermantel E, Leong KW. Biomedical applications of polymer-composite materials: a review. Composites Sci Techno 2001; 61(9): 1189-224.

57. 57- Kheirandish M, Borhani S, Malekpur Sh. The effect of nanoparticles of zinc oxide on the morphology and thermal stability of electrospun polystyren fibers. Eighth National Conference on Textile Engineering, Yazd University 2014. [Persian]

58. 58- Baghi SH, Sepehrian Azar A. Preparation and identification of hydrogel amphiphilate acrylamide and sodium alginate (I.P.N) and identification of its physical properties. Quarterly The Application of Chemistry in Environment 2014; 3(10): 23-32. [Persian]

59. 59- Langer R, Peppas NA. Advances in biomaterials, drug delivery, and bionanotechnology. AIChE J 2003; 49(12): 2990-3006.

60. 60- Chai Q, Jiao Y, Yu X. Hydrogels for biomedical applications: Their characteristics and the mechanisms behind them. Gels 2017; 3(1): 6.

61. 61- An J, Leeuwenburgh S, Wolke J, Jansen J. Mineralization processes in hard tissue: Bone. Biomineralization and Biomaterials: Elsevier 2016: 129-46.

62. 62- Borzouie Z, Hekmati-Moghadam S, Talebi A, Poor-Rajab F, Jebali A, Nikukar H, et al. Reconstitution of an artificial human testis using a 3 dimensional (3D) culture device. Human reproduction. Oxford univ press great clarendon st, Oxford OX2 6DP 2015.

63. 63- Xiao X, Wang W, Liu D, Zhang H, Gao P, Geng L, et al. The promotion of angiogenesis induced by three-dimensional porous beta-tricalcium phosphate scaffold with different interconnection sizes via activation of PI3K/Akt pathways. Sci Rep 2015; 5: 9409.

64. 64- Lee J, Cuddihy MJ, Kotov NA. Three-dimensional cell culture matrices: state of the art. Tissue Engineering Part B: Rev 2008; 14(1): 61-86.

65. 65- Narayani R, Rao KP. Controlled release of anticancer drug methotrexate from biodegradable gelatin microspheres. J microencapsulation 1994; 11(1): 69-77.

66. 66- Saralidze K, Koole LH, Knetsch ML. Polymeric microspheres for medical applications. Material 2010; 3(6): 3537-64.

67. 67- Chung HJ, Park TG. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Advanced drug delivery rev 2007; 59(4): 249-62.

68. 68- Xing X, Yu H, Zhu D, Zheng J, Chen H, Chen W, et al. Subwavelength and nanometer diameter optical polymer fibers as building blocks for miniaturized photonics integration. Optical Communication: InTech; 2012.

69. 69- Sachlos E, Czernuszka J. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater 2003; 5(29): 39-40.

70. 70- Kim BS, Mooney DJ. Engineering smooth muscle tissue with a predefined structure 1998; 41(2): 322-32.

71. 71- Garg T, Chanana A, Joshi R. Preparation of chitosan scaffolds for tissue engineering using freeze drying technology. IOSR J Pharm 2012; 2(1): 72-3.

72. 72- Hsu YY, Gresser JD, Trantolo DJ, Lyons CM, Gangadharam PR, Wise DL. Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices. J biomed mater Res 1997; 35(1): 107-16.

73. 73- Autissier A, Le Visage C, Pouzet C, Chaubet F, Letourneur D. Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process. Acta Biomaterialia 2010; 6(9): 3640-8.

74. 74- Whang K, Thomas C, Healy K, Nuber G. A novel method to fabricate bioabsorbable scaffolds. Polymer 1995; 36(4): 837-42.

75. 75- Sultana N, Wang M, editors. PHBV tissue engineering scaffolds fabricated via emulsion freezing/freeze-drying: Effects of processing parameters. Inter Conference on Biomed Engineer Tech 2011; 11(2011): 29-34.

76. 76- Mikos AG, Sarakinos G, Vacanti JP, Langer RS, Cima LG. Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures. Google Patents; 1996.

77. 77- Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, et al. Preparation and characterization of poly (L-lactic acid) foams. Polymer 1994; 35(5): 1068-77.

78. 78- Poursamar SA, Hatami J, Lehner AN, da Silva CL, Ferreira FC, Antunes APM. Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Material Sci Engineer 2015; 48: 63-70.

79. 79- Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly (D, L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterial 1996; 17(14): 1417-22.

80. 80- Ma Z, Kotaki M, Inai R, Ramakrishna S. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng 2005; 11(1-2): 101-9.

81. 81- Ma PX, Zhang R, Xiao G, Franceschi R. Engineering new bone tissue in vitro on highly porous poly (α‐hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001; 54(2): 284-93.

82. 82- Zhao J, Han W, Chen H, Tu M, Zeng R, Shi Y, et al. Preparation, structure and crystallinity of chitosan nano-fibers by a solid–liquid phase separation technique. Carbohydrate polymer 2011; 83(4): 1541-6.

83. 83- Lu T, Li Y, Chen T. Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering. Inte J Nanomedicine 2013; 8: 337-50.

84. 84- Geng X, Kwon O-H, Jang J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterial 2005; 26(27): 5427-32.

85. 85- Lee TC, Niederer P, Engineering ESf, Medicine. Basic Engineering for Medics and Biologists: An ESEM Primer: IOS Press; 2010.

86. 86- Jafari S, Sadeghi D, Yousefzadeh M, Solouk A. Electrospun Scaffolds Nanofibers for regeneration of diseased Vessels. J Textile Science Tech 2016; 5(4): 67-77. [Persian]

87. 87- Habibi S, Razagh Poor M, Allah Gholi Ghasri MR, Nazockdast H. Properties and Medical Applications of Electrospun Chitosan Nanofibers: A Review. J Textile Sci Technology 2014; 4(1): 43-55. [Persian]

88. 88- Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites Sci Tech 2003; 63(15): 2223-53.

89. 89- Akyash F, Tahajjodi SS, Sadeghian-Nodoushan F, Aflatoonian A, Abdoli AM, Nikukar H, et al. Reproductive biology, stem cells biotechnology and regenerative medicine: a 1-day national symposium held at Shahid Sadoughi University of Medical Sciences. Inter J Reprod BioMed 2016; 14(9): 553-56. [Persian]

90. 90- Baghersad S, Mansurnezhad R, GHasemi M, Mola HH, Morshed M. Coating of silk fabrics by pva/ciprofloxacin hcl nanofibers for biomedical applications 2016; 29(2): 171-84.

91. 91- Greiner A, Wendorff JH. Electrospinning: a fascinating method for the preparation of ultrathin fibers. Angewandte Chem Inter Edition 2007; 46(30): 5670-703.

92. 92- Lipol LS, Rahman MM. Electrospinning and Electrospun Nanofibers. World J Nano Sci Engineer 2016; 6.