Volume 25, Issue 6 (Aug 2017)                   JSSU 2017, 25(6): 501-511 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jamali Qarakhanlou B, Ebrahimi Kalan A, Tofighi A. Effect of resveratrol and aerobic exercise on some cardiovascular risk factors in rats with acute myocardial infarction . JSSU 2017; 25 (6) :501-511
URL: http://jssu.ssu.ac.ir/article-1-4071-en.html
Abstract:   (6244 Views)
Introduction: Coronary heart disease is the most common cause of myocardial ischemia. The present study was aimed to evaluate the effect of resveratrol and aerobic exercise together and singularly on some cardiovascular risk factors in rat model of acute heart failure due to isoproterenol application.
Materials and Methods: In this experimental study, 46 male Wistar rats were divided into five groups randomly as follows: the healthy control (CON), isoproterenol induced myocardial infarction without implementation (ISO), resveratrol treated rats (ISO+RES), exercise treated rats (ISO+EXE) and combination of resveratrol and exercise groups (ISO+RES+EXE). Rats in the resveratrol groups received daily dose of 25 mg/kg/bw of resveratrol and exercise groups ran 1 h/d and 8 weeks on treadmill. Subsequently, all animals received subcutaneous isoproterenol on two consecutive days at the end of experiment. Then, animals anesthetized and blood samples were collected for analysis.
Results: The results showed that pretreatment with a combination of resveratrol and aerobic exercise led to a significant reduction in troponin-I in the animals. Also, exercise training, resveratrol and combinations of them were prevented the increasing CRP indices, but there was not significant effect in these groups (P> 0.05). Pretreatment with exercise training as well as combination of resveratrol and exercise training caused a significant decrease serum cholesterol and triglyceride levels were compared to the isoproterenol group (P≤ 0.001). Pretreatment with resveratrol, exercise training and a combination of both significantly increased in HDL-C and pretreatment only in mixed group led to significant decrease in LDL-C compared to the isoproterenol group (P= 0.001).
Conclusion: Regular exercise and resveratrol supplementation is likely to be effective on cardiovascular risk factors and the combination of the two variables in the prevention of inflammation and will have a significant role in heart damage caused by myocardial infarction
Full-Text [PDF 735 kb]   (1669 Downloads)    
Type of Study: Original article | Subject: Exercise Physiology
Received: 2017/01/17 | Accepted: 2017/07/29 | Published: 2017/11/8

References
1. Gutterman DD. Silent myocardial ischemia. Circulation j 2009; 73(5): 785-97.
2. Hatmi Z, Tahvildari S, Motlag AG, Kashani AS. Prevalence of coronary artery disease risk factors in Iran: a population based survey. BMC Cardiovascular Disorders 2007; 7(1): 32.
3. Sittiwicheanwong R, Ariyapitipun T, Gulsatitporn S, Nopponpunth V, Abeywardena M, et al. Alterations of atherogenic low-density lipoproteins and serum fatty acids after 12 week moderate exercise training in sedentary Thai women. Asia Pacific j clinical nutrition 2007; 16(4): 602-8.
4. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacological Reviews 2007; 59|: 418-58.
5. Powers SK, Sollanek KJ, Wiggs MP, Demirel HA, Smuder AJ. Exercise-induced improvements in myocardial antioxidant capacity: the antioxidant players and cardioprotection. Free radical res 2014; 48(1): 43-51.
6. Calvert JW, Condit ME, Aragón JP, Nicholson CK, Moody BF, Hood RL, et al. Exercise protects against myocardial ischemia–reperfusion injury via stimulation of β3-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circulation res 2011; 108(12): 1448-58.
7. Hull S, Vanoli E, Adamson PB, Verrier RL, Foreman RD, Schwartz PJ. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation 1994; 89(2): 548-52.
8. Shephard RJ, Balady GJ. Exercise as cardiovascular therapy. Circulation 1999; 99(7): 963-72.
9. Cohen MV, Downey JM. Ischemic preconditioning: description, mechanism, and significance. Heart physiology and pathophysiology, 4th edn. Academic Press, San Diego 2001; 867-85.
10. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK. Coordinated induction of iNOS–VEGF–KDR–eNOS after resveratrol consumption: A potential mechanism for resveratrol preconditioning of the heart. Vascular pharmacology 2005; 42: 281-89.
11. Nounou HA, Deif MM, & Shalaby MA. Effect of flaxseed supplementation and exercise training on lipid profile, oxidative stress and inflammation in rats with myocardial ischemia. Lipids Health Dis 2012; 11(1): 129.
12. Ahn J, Cho I, Kim S, Kwon D, Ha T. Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet. J hepatology 2008; 49: 1019-28.
13. Afshin S, Mohammadi M, Vatankhah A, Alvandian E, Badalzadeh R, Mohaddes G , et al. Effect of Treadmill Exercise and Diosgenin on Biochemical Alterations in Isoproterenol-Induced Myocardial Infarction in Rats. Pharmaceutical Sci 2009; 15(1): 23- 30. [persion]
14. Hashemian M, Shabestari M, Jabari AF, Azizi H, The role of glucose-insulin-potassium therapy in the treatment of acute myocardial infarction: A review article. Journal of Sabzevar University of Medical Sciences 2012; 65: 206-16. [persion]
15. Dolinsky VW, Rogan KJ, Sung MM, Zordoky BN, Haykowsky MJ, Young ME & et al. Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. American J Physiology-Endocrinology and Metabolism 2013; 305(2): 243-53.
16. Lippincott Williams & Wilkins, ACSM's guidelines for exercise testing and prescription. Medicine; 2013.
17. Lobo Filho HG, Ferreira NL, Sousa RBd, Carvalho ERd, Lobo PLD, Lobo Filho JG. Experimental model of myocardial infarction induced by isoproterenol in rats. Revista Brasileira de Cirurgia Cardiovascular 2011; 26: 469-76.
18. Friedewald Wt, Levy Ri & Fredrickson Ds. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry 1972; 18: 499-502.
19. Zaafan Ma, Zaki Hf, El-Brairy Ai, Kenawy Sa. Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats. Bulletin of Faculty of Pharmacy, Cairo University 2013; 51: 35-41.
20. Tome-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón Mj, García-Almagro Fj, Ruiz-Ros Ja, et al. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovascular Drugs and Therapy 2013; 27: 37-48.
21. El-Mowafy A, El-Mesery M, Salem H, Al-Gayyar M & Darweish M. Prominent chemopreventive and chemoenhancing effects for resveratrol: unraveling molecular targets and the role of C-reactive protein. Chemotherapy 2010; 56: 60-65.
22. Timmers S, Konings E, Bilet L, Houtkooper Rh, Van De Weijer T, Goossens Gh, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell metabolism 2011; 14, 612-22.
23. Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villois P, et al. Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial. Current medicinal chemistry 2013; 20: 1323-31.
24. JIANG WJ. Sirtuins: novel targets for metabolic disease in drug development. Biochemical and biophysical res communications 2008; 373: 341-44.
25. Csiszar A, Labinskyy N, Podlutsky A, Kaminski Pm, Wolin Ms, Zhang C , et al. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. American J Physiology-Heart and Circulatory Physiology 2008; 294: 2721-35.
26. Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S & Et Al. Resveratrol increases vascular oxidative stress resistance. American J Physiology-Heart and Circulatory Physiology 2007; 292: 2417-24.
27. Miller Nj, Rice-Evans C ,Davies Mj, Gopinathan V & Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical sci 1993; 84: 407-8.
28. Paritha I. & Shyamala D. Effect of alpha-tocopherol on isoproterenol-induced changes in lipid and lipoprotein profile in rats. Indian journal of pharmacology 1997; 29: 399.
29. Fruchart Jc, Staels B & Duriez P. PPAR-alpha in lipid and lipoprotein metabolism, vascular inflammation and atherosclerosis. Atherosclerosis, Hypertension and Diabetes 2011; 8: 3-16.
30. Brownsey Rw, Boone An, Elliott Je, Kulpa Je, Lee Wm. Regulation of acetyl-CoA carboxylase. Biochem Soc Trans 2006; 34(2): 223-7.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb