Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome

Rezaei, Zahra; Kohan, Leila; Yavarian, Majid

Volume 24, Issue 11 (Feb 2017) JSSU 2017, 24(11): 861-867 | Back to browse issues page

Mendeley

Zotero

RefWorks

Rezaei Z, Kohan L, Yavarian M. Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome. JSSU 2017; 24 (11) :861-867
URL: http://jssu.ssu.ac.ir/article-1-3897-en.html

Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome

Zahra Rezaei

, Leila Kohan ^*

, Majid Yavarian

Abstract: (5303 Views)

Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this study was to assess the role of SIRT-1 rs7895833 polymorphism in the susceptibility of PCOS.

Methods: This case-control study was done on 456 Iranian women from March to February 2015. Blood samples were collected from 274 women with PCOS and 182 age matched (±5) healthy women at Shiraz Ghadir Mother and Child Hospital. After DNA extraction, SIRT1 rs7895833 genotype determination was done by Tetra-ARMS PCR. Data analysis was performed by SPSS version 18.

Results: In the dominant model for G allele (AG+GG vs. AA), AG+GG genotypes in SIRT1 rs7895833 gene polymorphism was associated with the increased risk of PCOS (OR: 2.01, %95CI:1.32-3.24, P=0.002). Moreover, there was a significant association between the G allele and PCOS (OR: 1.45, %95CI:1.10-1.91, P=0.008).

Conclusion: The results showed a possible association between SIRT1 rs7895833 gene polymorphism and susceptibility to PCOS.

Keywords: Polycystic Ovary Syndrome, SIRT1, Obesity, Polymorphism

Full-Text [PDF 772 kb] (1543 Downloads)

Type of Study: Original article | Subject: Genetics
Received: 2016/09/25 | Accepted: 2016/12/10 | Published: 2017/04/15

References

1. Khadilkar SS. Polycystic Ovarian Syndrome: Is It Time to Rename PCOS to HA-PODS? J Obstet Gynaecol India. 2016; 66(2):81-7.

2. Moran C, Arriaga M, Rodriguez G, Moran S. Obesity differentially affects phenotypes of polycystic ovary syndrome. Int J Endocrinol 2012; 317241.

3. Nandi A, Chen Z, Patel R, Poretsky L. Polycystic ovary syndrome. Endocrinol Metab Clin 2014; 43:123-147.

4. Legro RS. Obesity and PCOS: implications for diagnosis and treatment. Semin Reprod Med. 2012;30(6):496-506.

5. Hoeger KM, Oberfield SE. Do women with PCOS have a unique predisposition to obesity? Fertil Steril. 2012; 97(1):13-7.

6. Mario FM, do Amarante F, Toscani MK, Spritzer PM. Lean muscle mass in classic or ovulatory PCOS: association with central obesity and insulin resistance. Exp Clin Endocrinol Diabetes. 2012; 120(9): 511-6.

7. Pandey S, Bhattacharya S. Impact of obesity on gynecology. Womens Health 2010; 6(1): 107-17.

8. Clark SJ, Falchi M, Olsson B, Jacobson P, Cauchi S, Balkau B, et al. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity. Obesity 2011; 20(1): 178-185.

9. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458(7241): 1056-1060.

10. Qiang L, Wang H, Farmer SR. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol. 2007; 27(13): 4698-707.

11. Tao X, Zhang X, Ge SQ, Zhang EH, Zhang B. Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. Int J Clin Exp Pathol 2015; 8(7): 8276-83.

12. Kiyak Caglayan E, Engin-Ustun Y, Gocmen AY, Polat MF, Aktulay A. Serum sirtuin 1 levels in patients with polycystic ovary syndrome. J Obstet Gynaecol. 2015; 35(6): 608-11.

13. Martins IJ, Wilson AC, Lim WLF, Laws SM, Fuller SJ, Martins RN. Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and Type 2 diabetes. Sci Med 2012; 1(2): 1010.

14. Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 2010; 501(1):79-90.

15. Zarrabeitia MT. Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index. Arch Med Res 2012; 43(5): 363-68.

16. Botden IP, Zillikens MC, de Rooij SR, Langendonk JG, Danser AH, Sijbrands EJ,et al. Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine. Diabetes Care 2012; 35(2):424-426.

17. Shimoyama Y, Suzuki K, Hamajima N, Niwa T. Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese. Transl Res 2011;157(6):339-47.

18. Ewens KG, Jones MR, Ankener W, Stewart DR, Urbanek M, Dunaif A, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS One 2011;6:e16390.