Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome

Rezaei, Zahra; Kohan, Leila; Yavarian, Majid

Volume 24, Issue 11 (Feb 2017) JSSU 2017, 24(11): 861-867 | Back to browse issues page

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Rezaei Z, Kohan L, Yavarian M. Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome. JSSU 2017; 24 (11) :861-867
URL: http://jssu.ssu.ac.ir/article-1-3897-en.html

Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome

Zahra Rezaei

, Leila Kohan ^*

, Majid Yavarian

Abstract: (5619 Views)

Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this study was to assess the role of SIRT-1 rs7895833 polymorphism in the susceptibility of PCOS.

Methods: This case-control study was done on 456 Iranian women from March to February 2015. Blood samples were collected from 274 women with PCOS and 182 age matched (±5) healthy women at Shiraz Ghadir Mother and Child Hospital. After DNA extraction, SIRT1 rs7895833 genotype determination was done by Tetra-ARMS PCR. Data analysis was performed by SPSS version 18.

Results: In the dominant model for G allele (AG+GG vs. AA), AG+GG genotypes in SIRT1 rs7895833 gene polymorphism was associated with the increased risk of PCOS (OR: 2.01, %95CI:1.32-3.24, P=0.002). Moreover, there was a significant association between the G allele and PCOS (OR: 1.45, %95CI:1.10-1.91, P=0.008).

Conclusion: The results showed a possible association between SIRT1 rs7895833 gene polymorphism and susceptibility to PCOS.

Keywords: Polycystic Ovary Syndrome, SIRT1, Obesity, Polymorphism

Full-Text [PDF 772 kb] (1630 Downloads)

Type of Study: Original article | Subject: Genetics
Received: 2016/09/25 | Accepted: 2016/12/10 | Published: 2017/04/15

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