Journal of

Introduction: Propofol is an injectable anesthetics, which is used as sedation in surgery operations. The aim of the present study was to investigate the  analgesic activity of chlorpheniramine, and its comparison with morphine and fentanyl ( opiod agents) in intraperitoneal  propofol anesthesia in mice.

Methods: 40 adult male mice were randomly assigned in 4 groups. Anesthesia was induced by intraperitoneal administration of different combinations including: group1 (Normal saline and propofol),  group 2 ( chlorpheniramine and propofol), group 3 ( morphine and propofol) and finally group 4 (fentanyl and propofol).

Results: Time of surgical anesthesia in group 1 ( 12.7± 3.5) was shorter than group 2 (23.3 ±4.4) , group3 (25.2 ± 6.5), and group 4 (27.4± 3.7) (P < 0.05). Toe pinch score was significantly different in the first group (2.7± 0.5) and the second group (1.8 ± 0.7) (P < 0.05). Inhibition percentage in the second group (53.97) was more than first group (37.3) and it was ,also, less than third group (88.73) and fourth group (84.06) respectively. Significant decrease was observed in respiratory the rate from baseline values ( 148.9 ± 6.3) at all time points of anesthesia in all groups.

Conclusion: Based on the present results it is concluded that opioid agents (morphine and fentanyl) were induced good analgesic and anesthetic statues in combination with propofol in mice. Compared to morphine and fentanyl, chlorpheniramine analgesia is poor. Thus, chlorpheniramine ( H₁ antagonist) could be used in mice as analgesic and premedication agent in minor operations that there is no need to potent analgesics.