Clinicopathological significance of plasminogen activator inhibitor-1 gene polymorphism in breast cancer patients from North West of Iran

Younesi, M; Hosseinpour Feizi , MA; Pouladi, N

Volume 24, Issue 3 (Jun 2016) JSSU 2016, 24(3): 277-285 | Back to browse issues page

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Younesi M, Hosseinpour Feizi M, Pouladi N. Clinicopathological significance of plasminogen activator inhibitor-1 gene polymorphism in breast cancer patients from North West of Iran. JSSU 2016; 24 (3) :277-285
URL: http://jssu.ssu.ac.ir/article-1-3452-en.html

Clinicopathological significance of plasminogen activator inhibitor-1 gene polymorphism in breast cancer patients from North West of Iran

M Younesi

, MA Hosseinpour Feizi ^*

, N Pouladi

Abstract: (8090 Views)

Introduction: A common polymorphism 4G/5G in the promoter region of the Plasminogen activator inhibitor-1 (PAI-1) gene has been reported to influence the expression levels of PAI-1. According to the evidence, progression of breast cancer can be associated with elevated levels of PAI-1, it seems that evaluation of a possible correlation between the polymorphism and clinical status of breast cancer patients is reasonable.

Methods: This descriptive-analytical study included 160 unrelated patients from North West of Iran. According to established clinical criteria, these paitients were diagnosed with breast cancer. Based on previous study, PAI-1 4G/5G had been determined. In order to investigate the association of this polymorphism with clinicopathological features Fisher’s exact tests and SPSS software was used with a significance level of 0.05.

Results: All declared features of breast cancer regarding PAI-1 4G/5G polymorphism were investigated. Results indicated that PAI-1 4G/5G polymorphism positive correlation with several traditional prognostic factors, including tumor size, lymph node metastases and tumor stage.

Conclusion: Data showed that the patients with 5G/5G genotype are more susceptible to the development of breast cancer, while the paitients with 4G/4G and 4G/5G genotypes show lower sensitivity to the breast cancer. Therefore, the 4G allele likely has a protective role against the development of breast cancer in this cohort.

Keywords: PAI-1 4G/5G polymorphism, Breast Cancer, Clinical Status

Full-Text [PDF 611 kb] (1930 Downloads)

Type of Study: Original article | Subject: Genetics
Received: 2015/10/19 | Accepted: 2016/05/31 | Published: 2016/08/20

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