Changes of Serum Intercellular Adhesion Molecule – 1, Vascular Adhesion Molecule-1 and C – Reactive Protein in Middle-Aged Men with Heart Failure after Eight Weeks of Aerobic Exercise

Haghir, Hoda; Hejazi, Seyed Mahmood; Minaee, Shima

Volume 24, Issue 12 (Feb-Mar 2017) JSSU 2017, 24(12): 1013-1023 | Back to browse issues page

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Haghir H, Hejazi S M, Minaee S. Changes of Serum Intercellular Adhesion Molecule – 1, Vascular Adhesion Molecule-1 and C – Reactive Protein in Middle-Aged Men with Heart Failure after Eight Weeks of Aerobic Exercise. JSSU 2017; 24 (12) :1013-1023
URL: http://jssu.ssu.ac.ir/article-1-3631-en.html

Changes of Serum Intercellular Adhesion Molecule – 1, Vascular Adhesion Molecule-1 and C – Reactive Protein in Middle-Aged Men with Heart Failure after Eight Weeks of Aerobic Exercise

Hoda Haghir

, Seyed Mahmood Hejazi

, Shima Minaee ^*

Abstract: (8489 Views)

Introduction: The evidence has shown that expansion of cardiovascular disease has inflammation base, and general inflammation (systemic) plays a pivotal role in the development of atherosclerosis. The purpose of this research was evaluation of changes in intercellular adhesion molecule – 1, vascular adhesion molecule-1 and C – reactive protein in middle-aged men with heart failure after eight weeks of aerobic exercise.

Methods: Twenty four middle-aged men with heart failure were selected as volunteers, and were divided into two groups; the aerobic training and the control groups. Aerobic training program was eight weeks, three times per week with the intensity of 40%-70% maximum heart rate. Fasting blood samples were taken from all subjects before and after eight weeks of aerobic exercise. . Data were analyzed by paired sample t-test and independent sample t-test at a significance levels of P<0.05.

Results: In the aerobic training group, comparison within groups showed, serum levels of ICAM-1, VCAM-1 and CRP (respectively P=0.001, P=0.001 and P=0.001) were significantly reduced. There was a significant reduction in comparison between groups only for VCAM-1 (P=0.001) and CRP (P=0.002).

Conclusion: Aerobic exercise with reducing levels of inflammatory markers ICAM-1 and CRP may play an important role in the prevention and control of cardiovascular diseases in middle-aged men with heart failure.

Keywords: ICAM-1, VCAM-1, CRP, Heart Failure, Aerobic Exercise

Full-Text [PDF 1077 kb] (2094 Downloads)

Type of Study: Original article | Subject: Exercise Physiology
Received: 2016/02/27 | Accepted: 2016/07/23 | Published: 2017/05/24

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