Salivary gland tumors are uncommon within children and when they do arise, they mainly affect the major salivary glands. Minor salivary gland tumors are rare in children, which are responsible for less than 10% of all the cases. Pleomorphic adenoma is the most common tumor of the salivary glands in the all ages. A 10-year-old boy referred to the dentistry clinic with a swelling in the palate of adjacent unerupted right maxillary second molar. In sampling by curettage, clinical pathologist reported ameloblastoma. The patient was referred to the dental school of Shahid Sadoughi University of Medical Sciences for consultation. Second microscopic analysis showed a benign pleomorphic adenoma that was confirmed by special staining periodic acid-Schiff (PAS), immunohistochemistry cytokeratin(CK), and S100 staining. Pleomorphic adenoma of minor salivary gland of children should be considered as a differential diagnosis of intraoral swelling in the palate.
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