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Introduction:An association have been reported between diesel exhaust and endocrine disorders in several studies. Hence, this study aimed to investigate the effects of diesel exhaust on serum levels of T3, T4 and testosterone in male rats. Methods: In this laboratory experimental study, 24 male Wistar rats were randomly divided to 4 groups (6 series) consisting of the control group and groups exposed to 1, 4 and 8 hours daily diesel exhaust. After 10 weeks, blood samples were collected using cardiac puncture method and the levels of T3, T4 and testosterone were measured by radioimmunoassay following the serum collection. The study data were statically analyzed using ANOVA. Results: T3, T4 and testosterone serum levels did not significantly change in rats exposed to diesel exhaust for 1h/day compared to control rats, whereas these serum levels significantly increased in group exposed for 8h/day compared to control animals (P<0.05, P<0.01 and P<0.001, respectively). Conclusion: The study findings indicated that prolonged exposure to diesel exhaust results in increased thyroid and testicular activity, according to which exposure to diesel exhaust, particularly prolonged exposure can be accounted as an important factor associated with thyroid and sex glands disorders.

Keywords: Diesel Exhaust, Rat, T3, T4, Testosterone

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