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Introduction: Magnesium is an essential mineral in bone formation. This nutrient incorporates in bone metabolism and enhances bone mineralization. This study was designed to assess the effect of magnesium supplementation on alkaline phosphatase , osteocalcin, and also callus formation in women with long bone fracture. Methods: In this double-blind randomized placebo controlled trial, 32 women with long bone fracture, aged 20-45 years old, were randomly divided into the Mg group and control, receiving 250 mg magnesium oxide daily and placebo respectively for 8 weeks. Serum alkaline phosphatase and osteocalcin were measured at the beginning and the end point, and also callus formation was checked at the end of study. P value < 0.05 was considered as the significant level. Results: There was no significant difference between two groups in alkaline phosphatase and osteocalcin levels at the beginning and the end of study. Serum alkaline phosphatase and osteocalcin levels were increased in both groups, but they were not statistically significant. Furthermore, the callus formation, which revealed the fracture healing, was not different between 2 groups. Conclusion: This study concluded that Magnesium supplementation did not change the serum markers of bone formation and fracture healing however, further studies need to approve this finding.

Keywords: Alkaline phosphatase; Fracture; Magnesium; Osteocalcin

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