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Introduction: All the non-enzymatic materials in serum that have antioxidant properties are called antioxidant capacity. These materials protect the body against damage from free radicals. Therefore, this study aimed to compare the total antioxidant capacity of serum of diabetic patients with the healthy individuals as the control group. Methods: In this case-control study, 30 patients with type 2 diabetes referring to Zahedan Diabetes Center were assigned into the case group which were compared with 30 participants from control group, who were homogenous with the case croup in terms of age, gender and the other inclusion criteria. The antioxidant capacity of serum was evaluated with FRAP method. The study data were analyzed by T-test and Pearson’s correlation. Results: Serum total antioxidant capacity of patients compared with the control group showed a significant reduction (p<0.05). There was an inverse relationship between serum total antioxidant capacity and serum glucose concentrations in both diabetic patients and healthy subjects, though this relationship was not statistically significant in any of the two groups. No statistically significant relationship was found between total antioxidant capacity of serums and age. Conclusion: the study results revealed that the antioxidant immune system becomes weakened in type 2 diabetic patients. Considering the activity variations of the antioxidant enzymes in these patients can be helpful in reducing complications of diabetes.

Keywords: Antioxidant; Diabetic; Serum

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